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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Significant findings on liver disease
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
The restoration of hippocampal nerve de-myelination by methylcobalamin relates with the enzymatic regulation of homocysteine level in a rat model of moderate grade hepatic encephalopathy.
Study shows significant benefit
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
Vitamin B12 mitigates liver toxicity
Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats.
Findings support vitamin B12 use
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
Most Useful Reviews
8.3
Memory improvement
B12 greatly influences memory. After experiencing memory decline at 70, I had a blood test to check my B12 levels. I started chewing one tablet daily, and I’ve noticed significant improvement in my memory. My family also takes it, and it's genuinely helpful for maintaining cognitive function, especially concerning liver disease.
Read More
8.8
Improved energy levels
Excellent quality. The ingredients are safe and well-absorbed by the body. I had a severe deficiency of folic acid and B12, causing numbness and pain. This product significantly eased my issues, unlike the painful intramuscular injections I previously had. Since starting these pills, numbness has become rare. Their effect on my energy has been remarkable, and I recommend them for anyone with liver disease. Their sweet taste is a bonus; this is my fourth package, and I will continue to use them.
Read More
8.8
Vital for elderly
This complex is simply wonderful, containing essential B vitamins (B12, B6, B9) in active forms. It assists with chronic viral load and helps lower homocysteine levels, reducing the risk of cardiovascular diseases like stroke. It’s particularly important for the elderly at risk of liver disease. I hope my review has been helpful to you.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
9
Methylcobalamin aids liver health
Methylcobalamin protects against liver failure via engaging gasdermin E.
Significant findings on liver disease
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
The restoration of hippocampal nerve de-myelination by methylcobalamin relates with the enzymatic regulation of homocysteine level in a rat model of moderate grade hepatic encephalopathy.
Study shows significant benefit
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
Vitamin B12 mitigates liver toxicity
Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats.
Findings support vitamin B12 use
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
8
Vitamin B12 linked to liver risk
Genetically determined circulating micronutrients and the risk of nonalcoholic fatty liver disease.
Significant NAFLD risk association
We aimed to understand how vitamin B12 impacts the risk of developing nonalcoholic fatty liver disease (NAFLD). In this study, we used a method called Mendelian randomization, utilizing genetic data as a tool to draw connections between circulating nutrient levels and liver health. By analyzing information from a large group of participants—8434 cases of NAFLD and 770,180 controls—we sought to uncover any potential causal relationships.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Read More
8
Vitamin B12 aids liver health
Vitamin B12 blocked Trypanosoma brucei rhodesiense-driven disruption of the blood brain barrier, and normalized nitric oxide and malondialdehyde levels in a mouse model.
Study highlights liver disease impact.
We conducted a study to explore the potential benefits of vitamin B12 for liver health in the context of Trypanosoma brucei rhodesiense infection, which causes Human African Trypanosomiasis. Mice were divided into groups, with some receiving vitamin B12 either before or after the infection.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
8.8
Improved energy levels
Excellent quality. The ingredients are safe and well-absorbed by the body. I had a severe deficiency of folic acid and B12, causing numbness and pain. This product significantly eased my issues, unlike the painful intramuscular injections I previously had. Since starting these pills, numbness has become rare. Their effect on my energy has been remarkable, and I recommend them for anyone with liver disease. Their sweet taste is a bonus; this is my fourth package, and I will continue to use them.
Read More
8.8
Vital for elderly
This complex is simply wonderful, containing essential B vitamins (B12, B6, B9) in active forms. It assists with chronic viral load and helps lower homocysteine levels, reducing the risk of cardiovascular diseases like stroke. It’s particularly important for the elderly at risk of liver disease. I hope my review has been helpful to you.
Read More
8.3
Memory improvement
B12 greatly influences memory. After experiencing memory decline at 70, I had a blood test to check my B12 levels. I started chewing one tablet daily, and I’ve noticed significant improvement in my memory. My family also takes it, and it's genuinely helpful for maintaining cognitive function, especially concerning liver disease.
Read More
